Stimpy has invented a wondrous, diabolic machine... The Mutate-O-Matic! Unfortunately it explodes, and having pieces of a Mutate-O-Matic lying about is not a good thing. So Ren and Stimpy embark on an adventure that spans Mr. Horse's refrigerator, to the pound, and even... The Great Outdoors! References from the cartoon are frequent, coupled with lots of side-scrolling action. (mobygames)