Based upon Naoko Takeuchi's Sailor Moon sh?jo manga and anime series, the game takes place between the third season and fourth season of the anime series, which adapted the third and fourth arcs of the manga respectively, as players take control of either the five Inner Guardians or the four Outer Guardians in order to protect Crystal Tokyo by fighting against a group of rebels and several of their previously defeated enemies once again that were resurrected by the sorceress Apsu.