Captain America in: The Doom Tube of Dr. Megalomann (1987)

Players take on the role of Marvel superhero Captain America and must guide him around the Doom Tube base of Dr Megalomann. The base is a long tube inside another tube, splitting areas up into chambers around a central core. The virus has been released into the base, and players can only access areas below their immunity level. By defeating enemies they can collect ying-yang which boosts their immunity. (wikipedia.org)