Crash: Mind over Mutant takes place a year later after the events of where Crash of the Titans left off. The Titans, free from the control of Doctor Neo Cortex, have spread throughout the Wumpa Islands and cultivated their own societies and towns. All seems well until a rejuvenated Doctor Neo Cortex teams up with his old partner Doctor Nitrus Brio to invent a personal digital assistant, the "NV", that can control the minds of both mutants and bandicoots by transmitting bad Mojo (wikipedia)