Big Willy Unleashed takes place before the events of Path of the Furon and after Destroy All Humans! 2. The game is set in 1975, 6 years after Destroy All Humans! 2. Cryptosporidium 138 and his mentor, Orthopox 13, attempt to support the popularity of Big Willy, a fast food restaurant Orthopox owns. Pox reveals that the Big Willy food franchise is actually a scheme to dispose of the human bodies Crypto leaves lying around. (wiki)