Defiance continues the journey of the Vampire lord Kain and his lieutenant-turned-wraith Raziel. After having Raziel killed to be revived by the Elder God as a wraith during the events of Legacy of Kain: Soul Reaver, Kain travels backwards through time and is followed by Raziel into Nosgoth's past, uncovering the conspiratorial events that led to the land being doomed to an eternity of corruption.