Spider-Man: Shattered Dimensions has players control four different version of Spider-Man, each originating from a different universe in the Marvel Comics multiverse. When an artifact known as the Tablet of Order and Chaos is shattered during a fight between Spider-Man and Mysterio, Madame Web calls on four versions of Spider-Man from four realities to assist her in bringing four realities back into balance: the Amazing Spider-Man, Spider-Man Noir, Spider-Man 2099, and Ultimate Spider-Man.