Star Trek: Starfleet Command II: Empires at War (2000)

Star Trek Starfleet Command II: Empires at War is the sequel to Star Trek: Starfleet Command and the second in the series of real-time space combat games. The game features three singleplayer campaigns, two storyline campaigns, and a general conquest campaign. (wikipedia.org)
Genre: Strategy
Platform: Windows
Franchise: Star Trek
Expansions: Star Trek: Starfleet Command: Orion Pirates
Developer: Taldren
Publisher: Interplay Entertainment