Toonstruck

Toonstruck is an adventure game released in 1996 in which, although all the imagery is drawn and scanned into the game, the protagonist Drew Blanc (played and voiced by Christopher Lloyd) is an actual video-captured representation of the actor (the name is a pun, since the character has "drawn a blank" on coming up with a new idea for a character). Drew's sidekick, crudely named Flux Wildly, is a drawn character voiced by Dan Castellaneta.